I was messing around with this a while ago for a tune I wrote. Part of the head uses polychords, and I was trying to figure out how to approach them to add them to the blowing section, but I never quite got the hang of it, so I just left them out of that part.
The two voicings were as such:
Eadd4 / Cmaj:
(low to high)
Abadd4 / Bmaj:
226648 (the 22 part is tapped with the right hand)
For improvising, I was taking two major scales and splicing them together at the middle point of the chords. So for the first one, I'd play C major in the lower end of the instrument, and around actual middle C (not written middle C), I'd switch to E major. The two scales overlap below that with an A and a B, so it makes the transition fairly smooth.
For the second one, it would be B major on the bottom, and around the same point again at C#/Db above middle C, I'd switch to Ab major.
It's something I'd like to experiment more with in the future, but thinking about it in terms of polychords makes it much easier to comprehend.